Autophagy in Tri-o-cresyl Phosphate-Induced Delayed Neurotoxicity

Disturbed phospholipid homeostasis in endoplasmic reticulum initiates tri-o-cresyl phosphate-induced delayed neurotoxicity

Tri-o-cresyl phosphate (TOCP) is a widely used organophosphorus compound, which can cause a neurodegenerative disorder, i.e., organophosphate-induced delayed neurotoxicity (OPIDN). The biochemical events in the initiation of OPIDN were not fully understood except for the essential inhibition of neuropathy target esterase (NTE). NTE, located in endoplasmic reticulum (ER), catalyzes the deacylati...

Clinical Observation of Acute Delayed Neurotoxicity of Tri Ortho Cresyl Phosphate in Adult Hen

Clinical observation of acute delayed neurotoxicity study for 21 days of organophosphate using triorthocresyl phosphate (TOCP) as a model for organophosphate neurotoxicity, adult hens were dosed by oral gavage with 500mg/kg/bw single dose. Treated hens showed varying degrees of in-coordination, ataxia and paralysis at varying grades and on varying days of treatment mostly depending on the vario...

Involvement of oxidative stress in tri-ortho–cresyl phosphate-induced autophagy of mouse Leydig TM3 cells in vitro

BACKGROUND As a plasticizer, plastic softener, and flame-retardant, tri-ortho-cresyl phosphate (TOCP) is and has been widely used in industry and reported to have a toxic effect on the male reproductive system in animals besides neurotoxicity and immunotoxicity. We have reported that TOCP inhibits spermatogenesis and induces autophagy of rat spermatogonial stem cells, but it is still unknown wh...

Interim Specific Ground Water Criterion - Tri-ortho-cresyl phosphate (TOCP)

[A case of tri-ortho-cresyl-phosphate poisoning].